";s:4:"text";s:3898:" Patients should also be advised that if they are exposed, medical advice should be sought without delay.No adequate studies have been conducted in animals to determine whether corticosteroids have a potential for carcinogenesis or mutagenesis.Steroids may increase or decrease motility and number of spermatozoa in some patients.Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose. For chronic overdosage in the face of severe disease requiring continuous steroid therapy, the dosage of the corticosteroid may be reduced only temporarily, or alternate day treatment may be introduced.The initial dose of triamcinolone acetonide injectable suspension may vary from 2.5 mg to 100 mg per day depending on the specific disease entity being treated (see Hay fever or pollen asthma: Patients with hay fever or pollen asthma who are not responding to pollen administration and other conventional therapy may obtain a remission of symptoms lasting throughout the pollen season after a single injection of 40 mg to 100 mg.In the treatment of acute exacerbations of multiple sclerosis, daily doses of 160 mg of triamcinolone for a week followed by 64 mg every other day for one month are recommended (see In pediatric patients, the initial dose of triamcinolone may vary depending on the specific disease entity being treated. If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. This acute myopathy is generalized, may involve ocular and respiratory muscles, and may result in quadriparesis. The amount of benzyl alcohol from medications is usually considered negligible compared to that received in flush solutions containing benzyl alcohol. The range of initial doses is 0.11 to 1.6 mg/kg/day in 3 or 4 divided doses (3.2 to 48 mg/mFor treatment of joints, the usual intra-articular injection technique should be followed. With increasing doses of corticosteroids, the rate of occurrence of infectious complications increases. If experienced, these tend to have a Severe expression 1.
When reduction in dosage is possible, the reduction should be gradual.Since complications of treatment with glucocorticoids are dependent on the size of the dose and the duration of treatment, a risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used.Kaposi’s sarcoma has been reported to occur in patients receiving corticosteroid therapy, most often for chronic conditions. Select one or more newsletters to continue.