";s:4:"text";s:5201:"Clobetasol is used to treat certain scalp and skin conditions (e.g., psoriasis, dermatitis, rash).
Allergic contact dermatitis with corticosteroids is usually diagnosed by observing a If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used.
Special care may be needed.Elderly patients are more likely to have damaged skin through aging, and this may increase side effects. Amazon's Choice for clobetasol propionate ointment usp 0.05 Natural Herbal Cream, Moisturising Cream, Body Cream for Dry Skin, Itch Skin, Uncomfortable Skin, Itch Relief Cream 4.3 out of … Do not use your medicine more often than directed. Recovery of HPA axis function is generally prompt upon discontinuation of topical corticosteroids. These doses are approximately 1.4 and 0.04 times, respectively, the human topical dose of Clobetasol Propionate Ointment USP. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Potent steroids like clobetasol propionate are available only as prescription medicine. Call your doctor for medical advice about side effects. To do so may increase the chance of side effects.Talk to your pediatrician regarding the use of this medicine in children.
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If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary.Clobetasol Propionate Ointment USP is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.Clobetasol Propionate Ointment USP should not be used in the treatment of rosacea or perioral dermatitis, and should not be used on the face, groin, or axillae.Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal from treatment. While the number of patients is too small to permit separate analysis of efficacy and safety, the adverse reactions reported in this population were similar to those reported by younger patients. Manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on therapy.Patients applying a topical steroid to a large surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.Chemically, clobetasol propionate is (11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione, and it has the following structural formula:Clobetasol propionate USP has the empirical formula C Clobetasol Propionate Ointment USP, 0.05% contains clobetasol propionate USP 0.5 mg/g in a base of propylene glycol, sorbitan sesquioleate, and white petrolatum.Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. Clobetasol topical cream is available as a generic drug and a brand-name drug. Do not use double or extra doses without advice.Interactions are not expected. If a favorable response does not occur promptly, use of Clobetasol Propionate Ointment USP should be discontinued until the infection has been adequately controlled.Patients using topical corticosteroids should receive the following information and instructions:The following tests may be helpful in evaluating patients for HPA axis suppression:Long-term animal studies have not been performed to evaluate the carcinogenic potential of clobetasol propionate.Studies in the rat following subcutaneous administration at dosage levels up to 50 mcg/kg per day revealed that the females exhibited an increase in the number of resorbed embryos and a decrease in the number of living fetuses at the highest dose.Clobetasol propionate was non-mutagenic in three different test systems: the Ames test, the Clobetasol propionate has not been tested for teratogenicity when applied topically; however, it is absorbed percutaneously, and when administered subcutaneously it was a significant teratogen in both the rabbit and mouse. treatment should be limited to 2 consecutive weeks, and amounts greater than 50 g/week should not be used.Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [See USP Controlled Room Temperature]. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear.