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The elimination half-life of 1,2- and 1,3-dinitroglycerin is 36 and 32 minutes, respectively.
Sometimes doctors will prescribe a medicine for a condition that is not included in the patient information leaflets. Your list will be saved and can be edited at any time.The above information is provided for general
Because the hypotension associated with nitroglycerin overdose is the result of venodilatation and arterial hypovolemia, prudent therapy in this situation should be directed toward increase in central fluid volume. 100 mg 100's: NDC 17314-9220-1 Nitrostat dosage information (in more detail) What are some side effects that I need to call my doctor about right away? In one trial, patients had decreased exercise tolerance at the end of the nitrate interval.
Information for Patients. Store at Controlled Room Temperature 20°–25°C (68°–77°F) [see USP].What should I tell my doctor before taking NITROSTAT?
0.3-0.6 mg SL q5min up to 3 times; use at first sign of anginaDissolve under tongue or in buccal pouch; do not rinse mouth or spit for 5 minutes after administration1 tablet SL 5-10 minutes before activities likely to provoke angina attacksCrCl: 10-50 mg/min: Administer q24-72hr for prophylaxisCrCl <10 mL/min: Administer q72-96hr for prophylaxis0.3-0.6 mg SL q5min up to 3 times; use at first sign of anginaDissolve under tongue or in buccal pouch; do not rinse mouth or spit for 5 minutes after adminstration1 tablet SL 5-10 minutes before activities likely to provoke angina attacksEarly myocardial infarction, severe anemia, increased intracranial pressure, and known hypersensitivity to nitroglycerinRecent use (within several days) of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, or vardenafil) may cause dangerously low hypotension; the time course of the interaction appears to be related to the PDE-5 inhibitor half-lifeNarrow angle glaucoma (controversial: may not be clinically significant)Caution in MI or CHF, alcohol use, increased ICP (eg, head trauma, cerebral hemorrhage; potential contraindication), hyperthyroidism, hypertrophic cardiomyopathy, increased IOP, postural hypotension, volume depletion, low systolic BPSevere hypotension, particularly with upright posture, may occur with small doses of nitroglycerin particularly in patients with constrictive pericarditis, aortic or mitral stenosis, patients who may be volume- depleted; symptoms of severe hypotension (nausea, vomiting, weakness, pallor, perspiration and collapse/syncope) may occur even with therapeutic dosesInability to relieve chest pain after 3 doses indicates acute MI-rush to ER if possibleLack of burning/tingling does not indicate loss of potencyStore in original container at room temp; protect from moistureDo not change brands unintentionally as not all are bioequivalentTreat drug-induced headache with aspirin or acetaminophenProvide nitrate-free interval (10-12 hr or overnight) to avoid development of toleranceBenefits of sublingual nitroglycerin in patients with acute myocardial infarction or congestive heart failure not established; if one elects to use nitroglycerin in these conditions, careful clinical or hemodynamic monitoring must be used because of possibility of hypotension and tachycardiaUse smallest dose required for effective relief acute anginal attack; excessive use may lead to development of toleranceHypotension induced by nitroglycerin may be accompanied by paradoxical bradycardia and increased angina pectorisMay aggravate angina caused by hypertrophic cardiomyopathyIndustrial workers who have had long-term exposure to unknown (presumably high) doses of organic nitrates, tolerance rarely occurs; chest pain, acute myocardial infarction, and even sudden death have occurred during temporary withdrawal of nitrates from these workers, demonstrating existence of true physical dependenceDiscontinue drug if blurring of vision or drying of mouth occurs; excessive dosage of nitroglycerin may produce severe headachesNitroglycerin produces dose-related headaches, especially at start of nitroglycerin therapy, which may be severe and persist but usually subside with continued useLimited published data on use of nitroglycerin are insufficient to determine drug associated risk of major birth defects or miscarriage; in animal reproduction studies, there were no adverse developmental effects when nitroglycerin was administered intravenously to rabbits or intraperitoneally to rats during organogenesis at doses greater than 64-times the human doseSublingual nitroglycerin has not been studied in lactating women; not known if nitroglycerin is present in human milk or if nitroglycerin has effects on milk productionA: Generally acceptable.