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This, ever developing, technology makes the profiling of tube simple. 2.3; IMPACT, Ver.
SCHRÖDINGER SUITE 2012. To read this article in full you will need to make a paymentTCDB: the Transporter Classification Database for membrane transport protein analyses and information.The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction.Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis.Evolutionary origins of eukaryotic sodium/proton exchangers.The major amino acid transporter superfamily has a similar core structure as NaA limited universe of membrane protein families and folds.Membrane transport proteins: surprises in structural sameness.The crystal structure of a sodium galactose transporter reveals mechanistic insights into NaStructure and molecular mechanism of a nucleobase-cation-symport-1 family transporter.Structure and mechanism of an amino acid antiporter.Structure and mechanism of a Na+-independent amino acid transporter.Structure of a prokaryotic virtual proton pump at 3.2 A resolution.Molecular basis of transport and regulation in the Na(+)/betaine symporter BetP.Crystal structure of the carnitine transporter and insights into the antiport mechanism.Structure and mechanism of the lactose permease of Escherichia coli.Structure and mechanism of the glycerol-3-phosphate transporter from Structure of a glutamate transporter homologue from Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension.Sequence and hydropathy profile analysis of two classes of secondary transporters.Evolution of antiparallel two-domain membrane proteins: tracing multiple gene duplication events in the DUF606 family.Parallel topology of genetically fused EmrE homodimers.X-ray structure of EmrE supports dual topology model.Topologically random insertion of Emre supports a pathway for evolution of inverted repeats in ion-coupled transporters.Emulating membrane protein evolution by rational design.Structure and transport mechanism of the bacterial oxalate transporter OxlT.Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside.The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.Structure and function of Na(+)-symporters with inverted repeats.X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity.Structure of a glycerol-conducting channel and the basis for its selectivity.Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A.Crystal structure of a bacterial homologue of the kidney urea transporter.Ins and outs of major facilitator superfamily antiporters.Mechanism for alternating access in neurotransmitter transporters.Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1.The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway.Transport mechanism of a bacterial homologue of glutamate transporters.Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats.NhaA crystal structure: functional-structural insights.Beta-sheet-dependent dimerization is essential for the stability of NhaA NaRigidity of the subunit interfaces of the trimeric glutamate transporter GltT during translocation.A competitive inhibitor traps LeuT in an open-to-out conformation.Mechanism of substrate recognition and transport by an amino acid antiporter.The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter.Dynamics of the extracellular gate and ion-substrate coupling in the glutamate transporter.Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY.Na+: aspartate coupling stoichiometry in the glutamate transporter homologue GltPh.A reinvestigation of the secondary structure of functionally active vSGLT, the vibrio sodium/galactose cotransporter.Discontinuous membrane helices in transport proteins and their correlation with function.Ion-releasing state of a secondary membrane transporter.Unlocking the molecular secrets of sodium-coupled transporters.Identification of a chloride ion binding site in Na+/Cl -dependent transporters.Mechanism of chloride interaction with neurotransmitter:sodium symporters.Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents.How drugs interact with transporters: SGLT1 as a model.Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and NaThe binding sites for cocaine and dopamine in the dopamine transporter overlap.Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites.An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant.Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study.Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.Inability of diffusion to account for placental glucose transfer in the sheep and consideration of the kinetics of a possible carrier transfer.Transport of phosphate across the surface of Micrococcus pyogenes; nature of the cell inorganic phosphate.A general theory of membrane transport from studies of bacteria.Contributions to the theory of active transport: II.Hypothesis for mechanism of intestinal active transport of sugars.Moleculae, group and electron translocation through natural membranes.© 2010 Elsevier Ltd.
Nach oraler Gabe beträgt das scheinbare Verteilungsvolumen etwa 12 bis 26 l/kg. To submit a comment for a journal article, please use the space above and note the following:
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