";s:4:"text";s:5349:"The peak effect occurs within the first or second hour. Reports usually indicate that Lasix ototoxicity is associated with rapid injection, severe renal impairment, the use of higher than recommended doses, hypoproteinemia or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs. Nephrocalcinosis/nephrolithiasis has also been observed in children under 4 years of age with no history of prematurity who have been treated chronically with Lasix. PE study was negative, CXR revealed Lt lower PNA. The skin of some patients may be more sensitive to the effects of sunlight while taking furosemide.Hypertensive patients should avoid medications that may increase blood pressure, including over-the-counter products for appetite suppression and cold symptoms.Reversible elevations of BUN may occur and are associated with dehydration, which should be avoided, particularly in patients with renal insufficiency.Urine and blood glucose should be checked periodically in diabetics receiving Lasix, even in those suspected of latent diabetes.Lasix may lower serum levels of calcium (rarely cases of tetany have been reported) and magnesium. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not be adequately controlled with Lasix alone.Lasix is contraindicated in patients with anuria and in patients with a history of hypersensitivity to furosemide.In patients with hepatic cirrhosis and ascites, Lasix therapy is best initiated in the hospital. Because cross-sensitivity with furosemide has rarely been observed, bumetanide can be substituted for furosemide in patients allergic to furosemide. The median age was 73 years…”In addition: “We were able to adjust for a wide range of prognostic factors assumed to be important for pneumonia, including cardiovascular disease, chronic lung disease, liver cirrhosis, and renal disease.”The paper also says that “Our data indicated that pneumonia mortality increased with preadmission heart failure severity.” All text is copyright property of this site's authors. (furosemide) is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion.
Furosemide is predominantly excreted unchanged in the urine.