";s:4:"text";s:5781:" Michigan, USADepartment of Medicine, St John Hospital and Medical Center, Detroit.
Drug which can cause cyanide toxicity ? Neurotoxicity and hepatotoxicity 50. A significant reduction occurred in the incidence of preterm delivery (11.1% vs 23.5%) in the ACV and placebo arms, respectively. It is advisable to avoid massive use or prolonged use of the drug over wide areas in pregnant women, infants and children. A randomized, double-blind placebo-controlled trial among 200 HSV-2-positive pregnant women at 28 weeks of gestation was included in the study. In a case series of 48 patients with acyclovir neurotoxicity, herpes zoster infection was the most common indication for acyclovir therapy, followed by herpes simplex infection.
Isolated crystalluria and asymptomatic AKI are most common, but nausea/vomiting and flank/abdominal pain may occur. Acyclovir is not recommended for oral use in infants younger than 12 months of age because of lack of current safety and efficacy studies. Neurotoxicity of acyclovir in patients with end-stage renal failure treated with continuous ambulatory peritoneal dialysis. Japanese Journal of Geriatrics, Acyclovir-Induced Encephalopathy in a Patient with Normal Renal Function, Risk of Herpes Zoster in CKD: A Matched-Cohort Study Based on Administrative Data, Somatosensory Neurotoxicity: Agents and Assessment Methodology*, Dosing considerations for oral acyclovir following neonatal herpes disease, Association between Acyclovir Metabolite CMMG and Neuropsychiatric Adverse Reactions during Acyclovir Treatment in Dialysis Patients, Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), Acyclovir‐induced neuropsychosis successfully recovered after immediate hemodialysis in an end‐stage renal disease patient, Méningo-encéphalite herpétique, aciclovir et maladie VIH, une histoire en 3 actes, Valacyclovir neurotoxicity could occur in a hemodialysis patient even when treated using the dosage recommended for dialysis patients, Medikamentös induzierte neurologische und psychiatrische Störungen, Seizure-Inducing Drugs Used for the Critically Ill, Handbook of Essential Tremor and Other Tremor Disorders, Relation entre concentration et toxicité des antiherpétiques, Encephalopathy Induced by Oral Acyclovir in a Patient with Normal Renal Function, Acyclovir-induced coma in a young patient without preexisting renal impairment, Toxicité cérébrale et rénale de l'aciclovir chez un patient traité pour méningo-encéphalite, Annales Françaises d'Anesthésie et de Réanimation, Safety of Acyclovir in General Practice: A Review of the Literature, 10.1002/(SICI)1099-1557(199609)5:5<325::AID-PDS234>3.0.CO;2-1, Valacyclovir (VACV) is used increasingly to treat herpes zoster, although neuropsychiatric symptoms (VACV neurotoxicity (VAN) or acyclovir neurotoxicity), may accompany use of this drug.
Acyclovir (20 µg/mL) does not reproducibly alter cell-mediated immune responses of human peripheral blood leukocytes or affect human granulocyte progenitor cell growth in vitro.The oral bioavailability of ACV is low ~10%–30%. Michigan, USADepartment of Medicine, St John Hospital and Medical Center, Detroit.