";s:4:"text";s:4755:"Brexpiprazole is a novel D2 dopamine partial agonist investigational product currently in clinical trials for the treatment of depression, schizophrenia, and attention deficit hyperactivity disorder (ADHD). Brexpiprazole can make it harder for your body to control its own temperature. The study was designed to assess the efficacy and safety of brexpiprazole as an adjunctive treatment to standard antidepressant treatment. Ask your doctor about any risk.Brexpiprazole is not approved for use by anyone younger than 18 years old.Follow all directions on your prescription label and read all medication guides or instruction sheets.
Do not take two doses at one time.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Avoid driving or hazardous activity until you know how brexpiprazole will affect you. Version: 5.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Your family or other caregivers should also be alert to changes in your mood or symptoms.If you are pregnant, your name may be listed on a pregnancy registry to track the effects of brexpiprazole on the baby.It may not be safe to breastfeed while using this medicine. Package Price Qty; 5 mg: $50.00. It is a dopamine D 2 receptor partial agonist and has been described as a "serotonin–dopamine activity modulator" (SDAM). Availability: In stock. The longer you use brexpiprazole, the more likely you are to develop this disorder, especially if you are a diabetic or an older adult.uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;low white blood cell counts--fever, mouth sores, skin sores, severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors; orYou may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. CAS NO. Talk with your doctor if this occurs.This is not a complete list of side effects and others may occur. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … ;IC50 Value: N/A;Target: Dopamine Receptor;In vitro: Brexpiprazole (OPC-34712) is a close structural analog of aripiprazole and shares some of its pharmacological properties. It is easier to become dangerously overheated and dehydrated while you are taking this medicine.Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, High doses or long-term use of brexpiprazole can cause a serious movement disorder that may not be reversible. Your doctor should check your progress at regular visits. Brexpiprazole (OPC-34712), an atypical antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively.
Stopping suddenly may make your condition worse.Brexpiprazole may cause high blood sugar (hyperglycemia). Stay alert to changes in your mood or symptoms. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Your doctor may occasionally change your dose. We comply with the HONcode standard for trustworthy health information - Why Are Dementia Patients Getting Risky Psychiatric Drugs? You may report side effects to FDA at 1-800-FDA-1088.Initial dose: 1 mg orally once a day on Days 1 through 4Sometimes it is not safe to use certain medications at the same time. If you are diabetic, check your blood sugar levels on a regular basis while you are taking brexpiprazole.Store at room temperature away from moisture and heat.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The drug was approved by the U.S. Food and Drug Administration (FDA) on July 10, 2015, for the treatment of schizophrenia, and as an adjunctive treatment for depression. Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors. Brexpiprazole is an antipsychotic medication that is used to treat the symptoms of schizophrenia.It is also used together with other medications to treat major depressive disorder in adults.. Brexpiprazole may also be used for purposes not listed in this medication guide.