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The study consists of two parts: retrospective study (Part 1) and prospective study (Part 2).In this cohort, all patients received triple immunosuppressive regimen composing of tacrolimus (Prograft; Fujisawa Ireland Limited, Killorglin, Ireland), mycophenolate mofetil (Cellcept; Roche, Basel, Switzerland) 1.0–1.5 g per day and prednisolone (Guangdong Huanan Pharmacy Ltd., Dongguan, China) 30 mg per day.
Epub 2015 Sep 22.
All AEs were reviewed for severity, relation to study drugs and clinical importance. In the present study, we have examined the pharmacokinetics of oestrone in healthy postmenopausal women after cotreatment with a single oral dose of oestradiol and multiple doses of either ketoconazole, a probe CYP3A4 inhibitor or diltiazem, which is commonly used to treat angina pectoris and hypertension, and which also inhibits CYP3A4 activity. Effects of diltiazem on pharmacokinetics of tacrolimus in relation to ... CYP3A5 * 1/ * 3 genotype influences the blood concentration of tacrolimus in response to metabolic inhibition by ketoconazole. doi: 10.1128/AAC.02016-18.
eCollection 2019.Khalilieh SG, Yee KL, Sanchez RI, Fan L, Anderson MS, Sura M, Laethem T, Rasmussen S, van Bortel L, van Lancker G, Iwamoto M.Antimicrob Agents Chemother.
Ketoconazole is 83.7% plasma protein (mainly albumin) bound, and 15.3% is erythrocyte bound, resulting in only 1% of free drug. © 2020 American College of Clinical Pharmacology
You can also search for this author in 2017 Mar 13;18(3):621. doi: 10.3390/ijms18030621.Zhang J, Li L, Tang S, Hale TW, Xing C, Jiang C, Lü J.Am J Chin Med. 2018 Jun 22;13(6):e0199640.
Unable to load your collection due to an error I have read and accept the Wiley Online Library Terms and Conditions of Use*Eighteen subjects completed the study: one subject discontinued the study due to an adverse event (rash) and one subject withdrew consent because of a family emergency.
Calcium antagonists and renal protection. Pharmacokinetics of ketoconazole in normal subjects. Effects of diltiazem on pharmacokinetics of tacrolimus in relation to
Song: Wrote manuscript; W. Byon: Wrote manuscript; R.A. Boyd: Wrote manuscript; D. Zhang: Performed research; Z. Yu: Wrote manuscript, designed research, analyzed data; C. Dias: Wrote manuscript, designed research, analyzed data; A. Shenker: Wrote manuscript, designed research, analyzed data; F. LaCreta: Wrote manuscript, designed research, analyzed data.Please check your email for instructions on resetting your password. Please enable it to take advantage of the complete set of features!
Epub 2014 Oct 1.Grasela TH, Goodwin SD, Pasko MT, Walawander CA, Raebel MA.Ann Pharmacother. Given the limited clinical experience with concomitant administration of apixaban with strong inhibitors of CYP3A4 and P‐gp, co‐administration is generally not recommended The use of moderate inhibitors of CYP3A4 and/or P‐gp was allowed in phase III trials In conclusion, a 2‐fold and 1.4‐fold increase in apixaban exposure was observed with co‐administration of ketoconazole and diltiazem, respectively. J Antimicrob Chemother.
30873124 and 30873125) and Science and Technology Planning Project of Guangdong Province (no 2007B031511001). 2014 Dec;54(12):1321-9. doi: 10.1002/jcph.400. Apixaban is an orally active inhibitor of coagulation factor Xa and is eliminated by multiple pathways, including renal and non‐renal elimination. Besides, previous studies showed that diltiazem brings about not only functional, but also morphological improvement in tacrolimus-induced acute nephrotoxicity, and is effective in the prevention of ischemic damage,Diltiazem is a potent mechanism-based inhibitor of CYP3A.Venkataramanan R, Swaminathan A, Prasad T, Jain A, Zuckerman S, Warty V Staatz CE, Tett SE .
An efficient and simple method of DNA extraction from whole blood and cell lines to identify infectious agents.
Since apixaban is a direct reversible inhibitor of factor Xa, the primary concern with increases in exposure would be an increased risk of bleeding. Two single sequence studies evaluated the effect of ketoconazole (a strong dual inhibitor of CYP3A4 and P‐glycoprotein [P‐gp]) and diltiazem (a moderate CYP3A4 inhibitor and a P‐gp inhibitor) on apixaban pharmacokinetics in healthy subjects.In the ketoconazole study, 18 subjects received apixaban 10 mg on days 1 and 7, and ketoconazole 400 mg once daily on days 4–9. Schuster: Analyzed data; Y. Name must be less than 100 characters
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