";s:4:"text";s:4418:" So, he upped my glipizide to ER 10mg once daily. 4.5 hours. Glimepiride rated 6.7/10 vs Glipizide rated 6.2/10 in overall patient satisfaction. Side effects were no worse than Metformin alone.I was originally on metformin 500mg one daily when my A1C went to 7%. I was still running 300 fasting to over 500. I may try that since my glucoses are 140-150 off of glipizide despite exercise and mostly plant-based diet whereas it had been 104-116 on it (but hypoglycemia intolerableBlood sugar was stuck at 150 to 160 with no change for a while. My experience with glipizide xl and glipizide er i that glipizide xl keeps my blood sugars controlled much better that glipizide er. Then again I didn't change my eating habits or start exercising (but I am tall and thin, no weight problem here). After changing my diet pretty dramatically (cut out refined sugars and carb intake) my sugars came down. Just what I need!It's the first med I was given. ** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. Alcohol may affect blood glucose levels in patients with diabetes. With Glipizide XL, I have not experienced these fluctuations; however, the positive control appears to take effect much slower as this is a time-released form.The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.We comply with the HONcode standard for trustworthy health information - This didn't help so my doctor added glipizide 5mg once daily to my regimen. It never worked and I maxed it out at 40 mg per day. 4.3 hours. Family. Compare Glipizide vs GlipiZIDE XL head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. I've been taking the extended-release version of Glucotrol (Glucotrol XL) for the past 11 years, and it's been a decent supplement to my daily exercise up until recently, when my BG levels have been going up into the 200s right before, during, and after breakfast (even though morning fasting level upon waking is not too bad), and BG takes hours to come down until I've done enough exercise. Today is my first whole day with the regular Glucotrol (Glipizide) replacing most of the Extended-Release, and I see that after just the first two whole doses (morning and afternoon), BG is not only much improved, but my Average Glucose has dropped 20 points and my Time in Target Range has increased 10%.