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0000003407 00000 n Systemic vascular resistance was reduced in five of the eight patients.
The cumulative labetalol dose was not associated with adverse safety outcomes (A retrospective review of high-dose i.v. Our findings are also consistent with a variety of studies showing similar safety profiles for labetalol and nicardipine in ICH, subarachnoid hemorrhage, ischemic stroke, and acute hypertension. Multiple national stroke guidelines recommend labetalol as the prefer… 0000004340 00000 n -The recommended initial dose is 200 mg orally, followed in 6 to 12 hours by an additional dose of 200 or 400 mg orally, depending on the blood pressure response.-Thereafter, inpatient titration with labetalol hydrochloride tablets may proceed as follows: Day 1: 400 mg orally in 2 to 3 divided doses Day 2: 800 mg orally in 2 to 3 divided doses 8,22 – 26 These studies largely examined hemodynamic stability during the acute presentation, but Mayer et al 23 specifically did not find a survival difference between the initiation of labetalol …
To be able to analyze downstream infection development, patients started on antibiotics on hospital day 1 (n=68) were presumed to have arrived with an infection and also excluded from another cohort to specifically analyze infections.R version 3.2.1 (R Foundation for Statistical Computing, Vienna, Austria) was used for all analyses.The propensity for each patient to receive nicardipine was determined with the R package Twang using all covariates associated with receiving nicardipine by univariate analysis (Covariates not included in the propensity score were then tested for univariate associations with the outcomes of interest using Pearson’s χThis study included 1066 admissions. You have entered an invalid code Jason P Hecht, Pharm.D., BCPS, BCCCP In the case of harm, patients receiving both would be expected to have similar outcomes to those receiving just the harmful medication.Covariates in this study included age, sex, body mass index, atrial fibrillation, coronary artery disease, diabetes mellitus, hyperlipidemia, hypertension, peripheral vascular disease, prior stroke or transient ischemic attack, smoking status, substance abuse, admission ICH score, treatment with hypertonic saline or mannitol, and any surgical management of intracranial pressure (external ventricular drain, endoscopic evacuation, conventional craniotomy and evacuation, stereotactic evacuation, hemicraniectomy without evacuation, or “other”). After adjustment, compared with nicardipine alone, labetalol alone was associated with infection (odds ratio, 3.12; confidence interval, 1.27–7.64; Compared with nicardipine, labetalol was associated with increased in-hospital infections, but not mortality or modified Rankin Score >2. Urinary tract infections were recorded in 11.2% of patients, pneumonia in 5.0%, and bacteremia in 0.4%. 29 0 obj <> endobj @=l�\o�v�� g��2�������.�1(�+�B�]K�݁�b���f�B?�U�74dž�uH�}�����m�=�wm*7ߡ� #�[�m86�����A���04�ܢ��-�"*%Y���Iƈ-Z�� Intraperitoneal vancomycin treatment of multifocal methicillin-resistant
Pneumonia was prospectively recorded according to the standards of Get With The Guidelines-Stroke, but ICD-9 coding was used to identify urinary tract infections and bacteremia, which has variable capture rates and definitions.The timing of antihypertensive exposure used for categorizing a patient as receiving labetalol or nicardipine is also debatable. Department of Pharmacy, Beaumont Hospital, Dearborn, MI Labetalol or nicardipine was administered within the first 3 days of hospitalization for 525 admissions. 0000001157 00000 n
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