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Anti-Bacterial Agents/adverse effects* Cefepime; Cephalosporins/adverse effects* Drug Therapy, Combination/adverse effects* Female; Humans; Male; Middle Aged; Penicillanic Acid/adverse effects; Penicillanic Acid/analogs & derivatives* Piperacillin/adverse effects; Piperacillin, Tazobactam Drug Combination; Retrospective Studies ; Risk Assessment; Vancomycin/adverse effects* Young Adult; … Our Zosyn (piperacillin and tazobactam for injection, USP) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Ruizirastorza G, Barreiro G, Aguirre C "Reversible bone marrow depression by high-dose piperacillin / tazobactam." Link AS, Jr "Efficacy and safety of ticarcillin plus clavulanic acid and piperacillin in patients with lower respiratory tract infections." Intermittent Infusion for the Treatment of Hospitalized Patients with Complicated Intra-Abdominal Infection." Adverse events reported in 1% or less of pediatric patients receiving ZOSYN are consistent with adverse events reported in adults. "Product Information. We comply with the HONcode standard for trustworthy health information -
This is not a complete list of side effects and others may occur. Bow EJ, Rotstein C, Noskin GA, et al. J Infect Dis 155 (1987): 1242-832. Br J Haematol 95 (1996): 611-234. Clin Infect Dis 21 (1995): 1047-827. Tassler H, Cullmann W, Elhardt D "Therapy of soft tissue infections with piperacillin / tazobactam." What are side effects of Zosyn? Available for Android and iOS devices. Cerner Multum, Inc. "Australian Product Information." Pharmacotherapy 17 (1997): 166-926. O 03. Sweet RL, Roy S, Faro S, Obrien WF, Sanfilippo JS, Seidlin M, Mcgregor JA, Pastorek JA, Auger P, Summitt RL, Murray G, San "Piperacillin and tazobactam versus clindamycin and gentamicin in the treatment of hospitalized women with pelvic infection." There have been case reports of Neuromuscular excitability and convulsions have been reported when higher than recommended doses were given IV.Piperacillin therapy has been associated with an increased incidence of fever and rash in cystic fibrosis patients.-Frequency not reported: Petechial rash/purpura due to Piperacillin therapy has been associated with an increased incidence of fever and rash in cystic fibrosis patients.In a randomized, multicenter, controlled trial in critically ill adults (n=1200), this drug was found to be a risk factor for renal failure and associated with delayed recovery of renal function as compared to other beta-lactam antibacterial agents.A 51-year-old woman developed an acute onset of renal dysfunction after 6 days of therapy with this drug. Anesthesiology 72 (1990): 561-322. Bassilios N, Restoux A, Vincent F, Rondeau E, Sraer JD "Piperacillin/Tazobactam inducing seizures in a hemodialysed patient." South Med J 79 (1986): 255-630. In this trial, treatment-emergent adverse events were reported by 146 patients, 73 (26.7%) in the ZOSYN group and 73 (27.1%) in the cefotaxime/metronidazole group. Call your pharmacist for new medicine.Use Zosyn for the full prescribed length of time, even if your symptoms quickly improve. Keeping this in mind, it is of utmost importance to monitor the platelet count regularly during hospitalization and on subsequent follow-up visits, even after the most … Black, tarry stools "A randomized, open-label, multicenter comparative study of the efficacy and safety of piperacillin-tazobactam and cefepime for the empirical treatment of febrile neutropenic episodes in patients with hematologic malignancies." Adults. Twenty-five (11.0%) patients in the piperacillin/tazobactam group and 14 (6.5%) in the imipenem/cilastatin group (p > 0.05) discontinued treatment due to an adverse event.The second trial used a dosing regimen of 3.375 g given every 4 hours with an aminoglycoside.In a randomized, multicenter, controlled trial in 1200 adult critically ill patients, piperacillin/tazobactam was found to be a risk factor for renal failure (odds ratio 1.7, 95% CI 1.18 to 2.43), and associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs.Studies of ZOSYN in pediatric patients suggest a similar safety profile to that seen in adults.
3.375 g (3 g piperacillin and 0.375 g tazobactam) IV every 6 hours for 7 to 10 days.
Version: 8.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Pleasants RA, Walker TR, Samuelson WM "Allergic reactions to parenteral beta-lactam antibiotics in patients with cystic fibrosis." You may report side effects to FDA at 1-800-FDA-1088.Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.During the initial clinical investigations, 2621 patients worldwide were treated with ZOSYN in phase 3 trials. Bressler RB, Huston DP "Piperacillin-induced anemia and leukopenia." Tell any doctor who treats you that you are using Zosyn.Single-dose vials should be used immediately after reconstitution. Am J Med 69 (1980): 255-6110. Cerner Multum, Inc. "UK Summary of Product Characteristics." Antimicrob Agents Chemother (2006):7.
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