";s:4:"text";s:5535:" Supportive measures are required to restore electrolyte and pH balance. Periodic monitoring of serum electrolytes is recommended.DIAMOX modifies phenytoin metabolism with increased serum levels of phenytoin. This may be particularly important in the management of DIAMOX overdosage when complicated by the presence of renal failure.The recommended dosage is 1 capsule (500 mg) two times a day. four times daily) may be added to directly alkalinize the urine by increasing renal excretion of sodium, water, and bicarbonate, without increasing serum pH .
Not Feeling Well 6. Headache, malaise, fatigue, fever, pain at injection site, flushing, growth retardation in children, flaccid paralysis, anaphylaxis.Gastrointestinal disturbances such as nausea, vomiting, diarrhea.Blood dyscrasias such as aplastic anemia, agranulocytosis, leukopenia, thrombocytopenic purpura, melena.Abnormal liver function, cholestatic jaundice, hepatic insufficiency, fulminant hepatic necrosis.Metabolic acidosis, electrolyte imbalance, including hypokalemia, hyponatremia, osteomalacia with long-term phenytoin therapy, loss of appetite, taste alteration, hyper/hypoglycemia.Drowsiness, paresthesia (including numbness and tingling of extremities and face), depression, excitement, ataxia, confusion, convulsions, dizziness.Allergic skin reactions including urticaria, photosensitivity, Stevens- Johnson syndrome, toxic epidermal necrolysis. Acetazolamide increases lithium excretion and the lithium may be decreased.Acetazolamide and sodium bicarbonate used concurrently increase the risk of renal calculus formation.Sulfonamides may give false negative or decreased values for urinary phenolsulfonphthalein and phenol red elimination values for urinary protein, serum non-protein, and serum uric acid. In a bacterial mutagenicity assay, DIAMOX was not mutagenic when evaluated with and without metabolic activation.The drug had no effect on fertility when administered in the diet to male and female rats at a daily intake of up to 4 times the recommended human dose of 1000 mg in a 50 kg individual.Acetazolamide, administered orally or parenterally, has been shown to be teratogenic (defects of the limbs) in mice, rats, hamsters, and rabbits. The dosage should be adjusted with careful individual attention both to symptomatology and intraocular tension. In the eye, this inhibitory action of acetazolamide decreases the secretion of aqueous humor and results in a drop in intraocular pressure, a reaction considered desirable in cases of glaucoma and even in certain non-glaucomatous conditions. 10, FD&C red no. Acetazolamide should only be used by nursing women if the potential benefit justifies the potential risk to the child.The safety and effectiveness of Diamox Sequels in pediatric patients below the age of 12 years have not been established. Crystalluria, increased risk of nephrolithiasis with long-term therapy, hematuria, glycosuria, renal failure, polyuria.No specific antidote is known. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone.Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable.Acetazolamide may increase the effects of other folic acid antagonists.Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect.Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.Acetazolamide may prevent the urinary antiseptic effect of methenamine.
In circumstances of rapid ascent, such as in rescue or military operations, the higher dose level of 1000 mg is recommended. Sensitizations may recur when a sulfonamide is readministered irrespective of the route of administration. The dosage employed in the treatment of chronic simple (open-angle) glaucoma ranges from 250 mg to 1 g of acetazolamide per 24 hours, usually in divided doses for amounts over 250 mg. Imprinted in black ink, The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. DIAMOX is also indicated for the prevention or amelioration of symptoms associated with acute mountain sickness despite gradual ascent.Hypersensitivity to acetazolamide or any excipients in the formulation. Growth retardation has been reported in children receiving long-term therapy, believed secondary to chronic acidosis.Metabolic acidosis, which can be severe, may occur in the elderly with reduced renal function.In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant disease or other drug therapy.