";s:4:"text";s:3974:"Usual Adult Dose for Onychomycosis - Fingernail. The usual dose for dogs is 5 to 7 mg per pound (10 to 15 mg/kg) every 12 hours orally. They should not be used together in the treatment of adrenal hypercorticism.Isoniazid can affect ketoconazole levels. Ketoconazole should be used with caution in animals with liver disease or thrombocytopenia.Ketoconazole is available under the brand name Nizoral®, as well as various generic formulations. Evan Ware is a veterinary practitioner in Phoenix, Arizona. If the veterinary patient experiences increased enzyme levels along with anorexia, vomiting, and diarrhea, the veterinarian should be contacted immediately.Cats are more likely than dogs to experience side effects, particularly GI upset and hepatotoxicity.Other drugs can interact with ketoconazole, including cimetidine, antacids, methylprednisolone, cisapride, cyclosporine, theophylline, anticonvulsants, and heart medications.Ketoconazole should be used with caution with any other drugs that can be hepatotoxic. -Recommended as follow-up therapy for CNS infection. If you notice these symptoms contact your vet immediately and stop using the drug. Yeast normally live on the skin of dogs but when there is a change in the health of the skin or the immune system of the dog, yeast are more likely to multiply and a yeast infection results. Failure to complete the treatment will increase the risk of a relapse of the fungal infection.There is limited information on acute toxicity. The dose for cats is 2.5 to 5 mg per pound (5 to 10 mg/kg) every 12 hours orally. Blocking mammalian P-450 enzymes is the mechanism behind the reduction in steroid synthesis (cortisol and testosterone). Some animals can be more sensitive than others and therefore can experience certain side-effects.