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22. CMAJ. The selection and use of essential medicines. N Engl J Med. Pharmacoepidemiol Drug Saf. ACE inhibitors shouldn't be taken with an angiotensin receptor blocker or with a direct renin inhibitor. This drug-utilization study in a prescription database of more than 50,000 patients analyzed compliance, persistence, and switching behavior with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). 44.
Cardiology. Corrao G, Zambon A, Parodi A, et al. 26. WHO Expert Committee. All rights reserved. ACE inhibitors and ARBs may be used in patients with vascular disease or diabetes mellitus with end-organ damage because they produce equal reductions in … While switching was more common in ACE inhibitor users, compliance and persistence were similar between ACE inhibitors and ARBs. Your doctor may prescribe other medications in addition to an In rare cases, particularly for black people, women and smokers, Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve), decrease the effectiveness of Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Morimoto T, Gandhi TK, Fiskio JM, et al. 2008;178(10):1303-1311. A total of 51,181 patients initiated therapy on the predefined drugs. 3. Drugs. Menopause.
49. 11. Value Health. Pharmacoepidemiol Drug Saf. 9. Curr Hypertens Rep. 2001;3(6):488-492. Vegter S, de Jong-van den Berg LT.
Gogovor A, Dragomir A, Savoie M, Perreault S. Comparison of persistence rates with angiotensin-converting enzyme inhibitors used in secondary and primary prevention of cardiovascular disease. 2000;342(10):748]. Users of ARBs, on the other hand, were similar in terms of compliance, persistence, and switching behavior. Vink NM, Klungel OH, Stolk RP, Denig P. Comparison of various measures for assessing medication refill adherence using prescription data. Int J Clin Pract. BMJ. Differences in compliance were tested using logistic regression.
Drug-utilization patterns were investigated: incidence, dosage, 1-year compliance, long-term persistence, and switching behavior. 27. CMAJ. Br J Clin Pharmacol. The prescribed dosage often corresponded to the DDD. 2009;25(9):2303-2310. 2003;326(7404):1427. After 3 years of therapy, 24.2% of ACE inhibitor users had switched therapy, compared with 13.1% of ARB users ( In the present study we analyzed drug-utilization patterns of RAS inhibitors. 28. 39. Intern Med J. J Clin Epidemiol. Choice of first antihypertensive—comparison between the Irish and Dutch setting. 2000;321(7260):548-550. an evaluation of two methods using drug utilisation information. 6. Angiotensin-converting enzyme inhibitors are widely used as firstchoice RAS inhibitors because of long experience and low costs compared with ARBs. An evaluation of risk factors for adverse drug events associated with angiotensin-converting enzyme inhibitors. J Clin Hosp Pharm. Mancia G, Laurent S, Agabiti-Rosei E, et al. 21. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. 47. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. Penning-van Beest F, van Herk-Sukel M, Gale R, Lammers JW, Herings R. Three-year dispensing patterns with long-acting inhaled drugs in COPD: a database analysis. Brenner BM, Cooper ME, de Zeeuw D, et al; RENAAL Study Investigators. 2011;105(2):259-365. Drugs Aging. 2010;27(5):257-284. 2008;68(9): 1207-1225.
2009;27(11):2121-2158. By design, none of these patients had switched or permanently discontinued RAS therapy.
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