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";s:4:"text";s:5056:" Drugs Labor Induction. Given that the legal standard of care is based on reasonableness, it would seem prudent to adhere to a lower dosage of oxytocin as long as it was effective. Diseases & Conditions If you log out, you will be required to enter your username and password the next time you visit. 10 units/mL; Postpartum Hemorrhage. Diseases & Conditions Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. 2002 Add 10-40 units; not to exceed 40 units; to 1000 mL of nonhydrating IV solution and infuse at necessary rate to control uterine atony. Please confirm that you would like to log out of Medscape.

1072254-overview and formulary information changes. The most studied routes and doses of oxytocin are a single 10-unit intramuscular (IM) dose or an intravenous (IV) infusion of 20 to 40 units oxytocin in 1000 mL of saline or lactated Ringers solution, often infused at a rate of about 125 mL/hr.

796379-overview 2500091-overview informational and educational purposes only. This website also contains material copyrighted by 3rd parties. To avoid: manufacturer advises use electrolyte-containing diluent (i.e. Select one or more newsletters to continue. This was a generally well-conducted review. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcGl0b2Npbi1veHl0b2Npbi0zNDMxMzI= Your list will be saved and can be edited at any time.The above information is provided for general We comply with the HONcode standard for trustworthy health information - Labour wards, including midwife-led units, should have SOPs, which state the infusion solution, starting and escalation dosage of oxytocin, and indications and contraindications. 2002

The review included 61 studies with more than12,000 women.

Overall, oxytocin seems to be a safe method of inducing labour. Dosage Forms & Strengths injectable solution. Add 10-40 units; not to exceed 40 units; to 1000 mL of nonhydrating IV solution and infuse at necessary rate to control uterine atony0.5-1 mUnit/min IV, titrate 1-2 mUnit/min q15-60min until contraction pattern reached that is similiar to normal labor (usually 6 mUnits/min); may decrease dose after desired frequency of contraction reached and labor has progressed to 5-6 cm dilationOrphan designation for treatment of Prader-Willi syndromeSinus bradycardia, tachycardia, premature ventricular complexes & other arrhythmiasPermanent CNS or brain damage, and death secondary to asphyxiaUteroplacental hypoperfusion & variable deceleration of fetal heart rateSevere decreases in maternal systolic & diastolic blood pressure, increases in heart rate, systemic venous return & cardiac output, & arrhythmiaElective induction of labor is defined as the initiation of labor in a pregnant individual who has no medical indications for induction.Because the available data are inadequate to evaluate the benefits-to-risks onsiderations, oxytocin is not indicated for elective induction of labor.Unfavorable fetal positions or presentations, eg, transverse lies,which are undeliverable without conversion prior to deliveryWhere adequate uterine activity fails to achieve satisfactory progressContraindicated vaginal delivery, eg, invasive cervical carcinoma, active herpes genitalis, total placenta previa, vasa previa, & cord presentation or prolapse of cordFetal distress, polyhydramnios, partial placenta previa, prematurity, borderline cephalopelvic disproportion, previous major surgery of cervix or uterus (incl C-section), overdistension of uterus, grand multiparity, invasive cervical carcinoma, history of uterine sepsis or traumatic deliveryHyperstimulation of the uterus, with strong (hypertonic) &/or prolonged (tetanic) contractions, or a resting uterine tone of 15-20 mm H2O between contractions may occur, possibly resulting in uterine rupture, cervical & vaginal lacerations, postpartum hemorrhage, abruptio placentae, impaired uterine blood flow, amniotic fluid embolism, & fetal trauma including intracranial hemorrhageIf uterine hyperactivity occurs, discontinue immediatelyIntravenous preparations should be be administered by trained personnelRisk of severe water intoxication on prolonged administration due to its antidiuretic effectsUterine hypertonicity, spasm, rupture of the uterus, and tetanic contractions may occur from high dosesIM not recommended for labor induction/augmentationLactation: May be distributed milk; commencement of nursing should be delayed for at least 1 day when discontinued; use cautionA: Generally acceptable. 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