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The study is based on amantadine hydrochloride and methylphenidate hydrochloride (the active ingredients of Amantadine hydrochloride and Ritalin, respectively), and Amantadine hydrochloride and Ritalin (the brand names).
Some reports may have incomplete information.Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. To participate, parents and children have to be willing to comply with all requirements of the study.
Additional exclusion criteria will be hypertension, hypotension.
Amantadine was given as an infusion of 200 mg, and pain levels were measured before, during, and following treatment. Amantadine 40 A small study looked at amantadine versus placebo in relieving surgical neuropathic pain in patients with cancer. At screening, investigators conduct a psychiatric evaluation with the DSM-IV-TR criteria for ADHD and the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime diagnostic interview and perform a complete medical history and physical examination.The diagnosis of ADHD will be confirmed by a child and adolescent psychiatrist before participants will be initiated into the study. The protocol will be approved by the Institutional Review Board (IRB) of Tehran University of Medical Sciences.Patients will be randomized to receive amantadine or ritalin in a 1: 1 ratio using a computer-generated code.All study subjects will be randomly assigned to receive treatment using amantadine 100-150 mg depending on weight (100 mg/day for <30 Kg and 150 mg/day for >30 Kg) or ritalin at a dose of 20-30 mg/day depending on weight (20 mg/day for <30 Kg and 30 mg/day for >30 Kg) (group 2) for a 6 week double blind, randomized clinical.The principal measure of outcome will be the Parent and Teacher ADHD Rating Scale-IV that has been used extensively in Iran in school-age children and provides valid measures of behavioral abnormality and attention trial.Side effects will be systematically recorded throughout the study and will be assessed using a checklist that comprises 20 side effects including psychic, neurologic, autonomic and other side effects, administered by a child psychiatrist on days 7, 21and 42. PRODUCT ROUTE PRODUCT ROUTE azathioprine Oral azelastine Nasal baclofen Oral balsalazide disodium Oral beclomethasone dipropionate Inhalation benazepril Oral benazepril‐hydrochlorothiazide Oral benztropine Oral betamethasone External betaxolol Ophthalmic betaxolol Oral bethanechol Oral bisoprolol fumarate Oral bisoprolol‐hydrochlorothiazide Oral brimonidine tartrate (0.15% SOLUTION) …
However there are other types of non-stimulant medications that are primarily for adhd and are proven more effective. The investigators hypothesized that amantadine would be beneficial for treatment of ADHD, and this could be evaluated in a double blind, randomized, parallel group comparison of amantadine and ritalin.This will be a six-week, parallel group, randomized clinical trial undertaken in an outpatient child and adolescent clinic at Roozbeh Psychiatric Hospital in Tehran, Iran during April 2010-May 2010.50 male and female subjects, ages 6 to 17 years with a DSM-IV-TR diagnosis of ADHD will be study population of this trial.
Pain was reduced by 85% with the infusion. Informed consent will receive before the administration of any study procedure or dispensing of study medication in accordance with the ethical standards of the investigative site's institutional review board and with the Helsinki declaration of 1975, as revised in 2000.
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