";s:4:"text";s:3611:" It may take about 2 weeks or longer before the full effect of spironolactone occurs. Talk to your doctor about the possible risks of using this medication for your condition.This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.Follow your doctor's directions for your meals, including advice for a reduced-salt (sodium) diet and daily exercise program. By continuing to browse the site you are agreeing to our policy on the use of cookies. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Take spironolactone suspension consistently either with food or without food each time. Your doctor will order certain lab tests to check your body's response to spironolactone.Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking spironolactone.Do not let anyone else take your medicine. Patients who tolerate 25 mg once daily may have their dose increased to 50 mg once daily as clinically indicated. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme; website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Aldactone (spironolactone) is a medication that's used to treat many different disorders, from high blood pressure to fluid retention. Learn about reported side effects, related medication class, and daily life interactions. In patients receiving digoxin and spironolactone, the digoxin response should be monitored by means other than serum digoxin concentrations, unless the digoxin assay used has been proven not to be affected by spironolactone therapy. Maintenance dose should be individually determined.Based on the Randomized Aldactone Evaluation Study (RALES: see also section 5.1), treatment in conjunction with standard therapy should be initiated at a dose of spironolactone 25 mg once daily if serum potassium is ≤5.0 mEq/L and serum creatinine is ≤2.5 mg/dL. Potassium canrenoate, a metabolite of spironolactone, has been shown to cause myeloid leukaemia in rats.Lithium - concurrent use of lithium and spironolactone may result in increased lithium concentrations and lithium toxicity (weakness, tremor, excessive thirst, and confusion) due to decreased lithium excretion.
The metabolites are excreted primarily in the urine and secondarily in bile. • Spironolactone is contraindicated in paediatric patients with moderate to severe renal impairment. Dosage should be adjusted in accordance with response and tolerance. • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.