";s:4:"text";s:3824:"Studies on morphological outcome of cyclosporine-associated arteriolopathy after discontinuation of cyclosporine in renal allografts. Although indispensable in the management of solid organ transplantation, cyclosporine and tacrolimus can cause acute and chronic nephrotoxicity.
Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of allograft rejection in solid organ transplantation.
Epub 2005 Jul 5.Jhao YT, Chiu CH, Chen CF, Chou TK, Lin YW, Ju YT, Wu SC, Yan RF, Shiue CY, Chueh SH, Halldin C, Cheng CY, Ma KH.Cells. Please enable it to take advantage of the complete set of features! Available for Android and iOS devices. Methods: Six groups of five weight-matched animals each, were used for the study. Unable to load your collection due to an error Transplantation 64: 1236–1240, 1997. Clinical monitoring of renal function is necessary and differentiation between cyclosporine-induced nephrotoxicity, allograft rejection, and other causes of impaired renal function should be determined prior to cyclosporine dosage adjustments.Moderate Potential Hazard, High plausibility. Major Potential Hazard, High plausibility. Cyclosporine causes a reversible reduction in renal blood flow and glomerular filtration rate resulting in increased serum creatinine and blood urea nitrogen. Sandimmune and Neoral are not bioequivalent and should not be used interchangeably without physician supervision.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2005 Nov;289(5):F1020-30.
Cyclosporine Nephrotoxicity* BERNHARD RYFFEL AND MICHAEL J. MIHATSCH Preclinical Research Sandoz Ltd., and Department of Pathology, Kantonsspital, CH-4002 Basel, Svitzerlund ABSTRACT Cyclosporine (CSA) is a new immunosuppressant which has selectivity for the immune system and is without systemic side effects at therapeutic doses. The concern that chronic calcineurin inhibitor (CNI) nephrotoxicity was a major long-term problem should have been widely understood in the mid-1990s through the longer-term follow-up of trials of CsA treated patients [8, 9].
Renal biopsies from these patients can demonstrate interstitial fibrosis, tubular atrophy, global or segmental glomerulosclerosis, or smooth vascular muscle damage.
Transplant Proc. Clipboard, Search History, and several other advanced features are temporarily unavailable. Histological changes appear as obli … Kidney Int 50: 1110–1117, 1996. Aims To identify the predictive factors for ciclosporin A (CyA)-associated nephrotoxicity (CAN) in children with minimal change nephrotic syndrome (MCNS). (See "Cyclosporine and tacrolimus nephrotoxicity".) Chronic nephrotoxicity. The efficacy and use of these agents in specific conditions, including organ transplantation and immune-mediated diseases, are discussed separately in the topic reviews addressing the treatment of each disorder.