";s:4:"text";s:4248:" Pharmacodynamic interactions may be caused by a large variety of mechanisms. Then the target propofol concentration was reduced by 50% and finally discontinued approximately 10 min before skin closure. The alfentanil concentrations associated with a 50% probability (ECResults: With blood propofol concentrations increasing from 2 to 10 micro gram/ml, the ECDiscussion: We defined the pharmacodynamic interaction between propofol and alfentanil for suppression of responses to perioperative stimuli during lower abdominal surgery. The possibility of an additive interaction between alfentanil and propofol was examined by the equation Equation 6and the possibility of a nonadditive interaction between alfentanil and propofol was examined by the equation Equation 7.
Subjects in Arm 1 received 30 mg of tolvaptan, 80 mg of furosemide, and 30 mg of tolvaptan + 80 mg of furosemide. COVID-19 is an emerging, rapidly evolving situation. Blood propofol concentrations were fairly stable throughout the surgical procedure in all patients (The pharmacodynamic interactions between propofol and alfentanil for laryngoscopy, intubation, the opening of the peritoneum, and awakening were determined by logistic regression as described for the analysis of the pharmacodynamic interaction between fentanyl and desflurane. In addition, all patients received computer-controlled infusion of alfentanil (initial target concentration 50 ng/ml).
ANESTHESIOLOGY 75:A588, 1991. In view of this, we considered it appropriate to study centchroman, another long-term used drug, along with losartan to explore the possibility of pharmacokinetic and pharmacodynamic (PK–PD) interaction, if any. 2000 Sep;52(9):1075-83. doi: 10.1211/0022357001774994.Ann Pharmacother. Every 20-30 min an additional arterial blood sample for the determination of blood propofol concentrations was collected in glass tubes containing potassium oxalate.
Please enable it to take advantage of the complete set of features! In addition, the mean propofol concentration was calculated for each patient by averaging the concentrations measured in all blood samples collected from that patient intraoperatively. Clipboard, Search History, and several other advanced features are temporarily unavailable. For patients in group B, 20 ml glucose 5% was added to 40 ml propofol (10 mg/ml) to obtain 60 ml propofol, 6.66 mg/ml. Following oral administration, losartan is rapidly absorbed, reaching maximum concentrations 1–2 hours post-administration. 1993 Dec;92(6):2653-9. doi: 10.1172/JCI116881.Vaidyanathan S, Valencia J, Kemp C, Zhao C, Yeh CM, Bizot MN, Denouel J, Dieterich HA, Dole WP.Int J Clin Pract. The effects of alfentanil are caused by interaction with opioid receptors. This site needs JavaScript to work properly. Combined irbesartan / hydrochlorothiazide (HCTZ) formulations are often used clinically. In the patients that remained conscious with the initial target alfentanil concentration, unconsciousness was induced when the target alfentanil concentration was increased by 100-200 ng/ml.The number and type of responses that were noted during the intraabdominal part of surgery are presented in Alfentanil significantly affected the blood propofol concentration at which the patients regained consciousness (None of the patients reported awareness for any perioperative event. No clinically significant changes were noted in the pharmacokinetic profiles of tolvaptan and furosemide or tolvaptan and HCTZ when coadministered. Wolters Kluwer Anesthetics, intravenous: alfentanil; propofol. Subjects in Arm 2 received 30 mg of tolvaptan, 100 mg of HCTZ, and 30 mg pf tolvaptan + 100 mg of HCTZ. Alfentanil-propofol interactions for laryngoscopy, intubation, skin incision, the opening of the peritoneum, and awakening were determined by logistic regression over the three groups (n = 21).