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Each 500 mg vial contains 500 mg of acyclovir and 49 mg of sodium, and each 1,000 mg vial contains 1,000 mg acyclovir … In neonatal herpes simplex infections, doses of 15 mg/kg or 20 mg/kg (infused at a constant rate over 1 hour every 8 hours) have been used; the safety and efficacy of these doses are not known.10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.20 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.Obese patients should be dosed at the recommended adult dose using Ideal Body Weight.For patients who require dialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours. DIN: 02236926: Product Code: C302510: Description: 50 mg/mL SD Vial: Size/Format: 10 mL: Unit/Pack: 10: GTIN 12 Barcode Unit of Use (Vial) 629336305100: GTIN 12 Barcode Selling Unit (Tray/Carton) Testicular atrophy and aspermatogenesis were observed in rats and dogs at higher dose levels.Acyclovir administered during organogenesis was not teratogenic in the mouse (450 mg/kg/day, PO), rabbit (50 mg/kg/day, SC and IV) or rat (50 mg/kg/day, SC). Acyclovir levels in plasma ranged from <0.01 to 0.28 mcg/mL in 8 patients with normal renal function, and from <0.01 to 0.78 mcg/mL in 1 patient with impaired renal function. You may report side effects to FDA at 1-800-FDA-1088.We comply with the HONcode standard for trustworthy health information - Acyclovir is a synthetic nucleoside analog active against herpes viruses. These exposures resulted in plasma levels the same as, 4 and 9, and 1 and 2 times, respectively, human levels.There are no adequate and well-controlled studies in pregnant women. These exposures resulted in plasma levels the same as, 4 and 9, and 1 and 2 times, respectively, human levels.There are no adequate and well-controlled studies in pregnant women. At 450 mg/kg/day, plasma concentrations in both the mouse and rat bioassay were lower than concentrations in humans.Acyclovir did not impair fertility or reproduction in mice (450 mg/kg/day, PO) or in rats (25 mg/kg/day, SC). Acyclovir for Injection, USP is intended for intravenous infusion only, and should not be administered topically, intramuscularly, orally, subcutaneously, or in the eye. The occurrence rate of birth defects approximates that found in the general population. (NDC 55390-613-20). There was no statistically significant difference in the incidence of tumors between treated and control animals, nor did acyclovir shorten the latency of tumors. The chemical name of acyclovir sodium is 9-[(2-Hydroxyethoxy)methyl] guanine, and has the following structural formula:The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. The only major urinary metabolite detected is 9-carboxymethoxymethylguanine accounting for up to 14.1% of the dose in patients with normal renal function.The half-life and total body clearance of acyclovir are dependent on renal function as shown in Table 2.Acyclovir was administered at a dose of 2.5 mg/kg to 6 adult patients with severe renal failure. Testicular atrophy and aspermatogenesis were observed in rats and dogs at higher dose levels.Acyclovir administered during organogenesis was not teratogenic in the mouse (450 mg/kg/day, PO), rabbit (50 mg/kg/day, SC and IV), or rat (50 mg/kg/day, SC). Acyclovir is a synthetic nucleoside analog active against herpes viruses. Higher concentrations (e.g., 10 mg/mL) may produce phlebitis or inflammation at the injection site upon inadvertent extravasation. The occurrence rate of birth defects approximates that found in the general population. Administration of acyclovir by intravenous infusion must be accompanied by adequate hydration.When dosage adjustments are required, they should be based on estimated creatinine clearance (see Approximately 1% of patients receiving intravenous acyclovir have manifested encephalopathic changes characterized by either lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures, or coma. Acyclovir capsule is a formulation for oral administration.
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