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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Diseases & Conditions Dr. Emmy Graber says, “The dosing varies greatly from patient to patient. Subsequently, the dose may be adjusted according to patient response. Spironolactone is a medication usually used for fluid retention but sometimes used to treat hair loss.
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Spironolactone, also known by the brand name Aldactone®, is used to reduce fluid accumulation that may occur in disorders such as heart failure or liver disease in dogs and cats. For oral dosage form (suspension): Adults—At first, 20 milligrams (mg) (4 milliliters [mL]) per day. Select one or more newsletters to continue. Children—Use and dose must be determined by your doctor.
Our general interest e-newsletter keeps you up to date on a wide variety of health topics.In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt) and potassium.
Controlled studies in pregnant women show no evidence of fetal risk.Aldosterone antagonist with diuretic and antihypertensive effects; competitive binding of receptors at aldosterone-dependent Na-K exchange site in distal tubules results in increased excretion of Na+, Cl-, and water and retention of K+ and H+Increases testosterone clearance and estradiol production; blocks conversion of potent androgens to weaker ones in peripheral tissuesPeak serum time: 2.6-4.3 hr (tablet); 0.5-1.5 hr (PO suspension); 2.5-5 hr (PO suspension, active metabolite)A high fat and high calorie meal (57% of the ~1000 kcal of the meal were from fat) increased the bioavailability of spironolactone (as measured by AUC) by ~90%Metabolites: Canrenone, 7-alpha-thiomethylspirolactone, 6-beta-hydroxy-7-alpha-thiomethylspirolactone (active)Half-life (tablet): 1.3-1.4 hr (parent drug); 16.5 hr (canrenone); 13.8 hr (7-α-[thiomethyl] spirolactone [TMS]); 15 hr (6-ß-hydroxy-7-α-[thiomethyl] spirolactone [HTMS])Half-life (PO suspension): 1-2 hr (parent drug); 10-35 hr (canrenone, 7-α-[thiomethyl] spirolactone [TMS], 6-ß-hydroxy-7-α-[thiomethyl] spirolactone [HTMS])Take with or without food; take consistently with respect to foodPO suspension: Store at 68-77°F (20-25°C); excursions permitted to 59-86°F (15-30°C); shake well before use, dispense in a tight container as defined in the USPAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. This website also contains material copyrighted by 3rd parties. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.If you miss a dose of this medicine, take it as soon as possible. For oral dosage form (tablets): Adults—At first, 25 milligrams (mg) once a day. You may have to take high blood pressure medicine for the rest of your life. All rights reserved. for a total of 9.0 grams.For treatment of syphilis, a total of 30–40 grams in equally divided doses over a period of 10–15 days should be given. Compiled by pharmacists. If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. Spironolactone oral tablet is available as the brand-name drug Aldactone and as a generic drug…
891897-overview You may take this medicine with or without food, but it should be taken the same way (with or without food) each day.
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