";s:4:"text";s:4552:" For best results, keep using the medication as directed. The microscopic changes were no longer present at Recovery Week 14 at 0.1 times the MRHD and were partly recovered in the remaining treatment groups. Avodart may affect the way other medicines work, and other medicines may affect how Avodart works.Know the medicines you take. The inactive excipients in the capsule shell are ferric oxide (yellow), gelatin (from certified BSE-free bovine sources), glycerin, and titanium dioxide.
Increased placental weights in rabbits were also observed, with no-effect levels less than the MRHD of 0.5 mg daily Although dutasteride is secreted into human semen, the drug concentration in the human female partner is approximately 100 times less than concentrations producing abnormalities of male genitalia in animal studies In a rabbit embryo-fetal development study, doses 28 times the MRHD (doses of 30 mg/kg/day or greater), based on average blood levels in men, were administered orally on Gestation Days 7 to 29 (during organogenesis and the late period of external genitalia development). At Month 12, the mean percent change in prostate volume across the 3 trials pooled was -24.7% for dutasteride and -3.4% for placebo; the mean difference (dutasteride minus placebo) was -21.3% (range: -21.0% to -21.6% in each of the 3 trials, Differences between the 2 groups were statistically significant from baseline at Month 3 in all 3 trials and were maintained through Month 12. Histological evaluation of the genital papilla of fetuses revealed evidence of feminization of the male fetus as well as fused skull bones and increased placental weights at all doses in the absence of maternal toxicity.
However, the effect of Avodart on male fertility is not known.These are not all the possible side effects of Avodart. Therefore, in cases of suspected overdosage, symptomatic and supportive treatment should be given as appropriate, taking the long half-life of dutasteride into consideration.Avodart is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase, an intracellular enzyme that converts testosterone to DHT.Dutasteride is chemically designated as (5α,17β)-N-{2,5 bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide. When including the open-label extensions, 1,009 male subjects were exposed to Avodart for 3 years and 812 were exposed for 4 years. These reactions have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal connection to Avodart.Hypersensitivity reactions, including rash, pruritus, urticaria, localized edema, serious skin reactions, and angioedema.Dutasteride is extensively metabolized in humans by the cytochrome P450 (CYP)3A4 and CYP3A5 isoenzymes. No cases of breast cancer were reported in any treatment group in the 4-year CombAT trial or the 4-year REDUCE trial.The relationship between long-term use of dutasteride and male breast neoplasia is currently unknown.Over 4,800 male subjects with BPH were randomly assigned to receive 0.5-mg Avodart, 0.4-mg tamsulosin, or combination therapy (0.5-mg Avodart plus 0.4-mg tamsulosin) administered once daily in a 4-year double-blind trial. It helps improve urinary flow and may also reduce your need for prostate surgery later on. Avodart (dutasteride) prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body. Proscar (finasteride) and Avodart (dutasteride) are used to treat symptoms of benign prostatic hyperplasia in men with an enlarged prostate..