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Hyperuricemia is commonly associated with hypertensionWe systematically searched the electronic databases, Medline, PubMed, EMBASE, and the Cochrane Library for Central Register of Clinical Trials, using the MESH terms “allopurinol,”“blood pressure,”“blood pressure monitoring, ambulatory,” and “hypertension,” with the key words “xanthine oxidase inhibitor,”“uric acid,” and “oxypurinol.” We limited our search to studies in human patients and English language in peer‐reviewed journals from 1966 to February 2012. COVID-19 is an emerging, rapidly evolving situation. The jury is still out, Crystal-proven Gout and Characteristic Gout Severity Factors Are Associated with Cardiovascular Disease, Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017, Effect of Xanthine Oxidase Inhibition on Arterial Stiffness in Patients With Chronic Heart Failure, MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank, Effects of pharmacological reversal of hyperuricemia on features of the metabolic syndrome in patients with gouty arthritis, Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease, Age-differential association between serum uric acid and incident hypertension, Cardiac and renal protective effects of urate-lowering therapy, Effect of Uric Acid Lowering on Renin-Angiotensin-System Activation and Ambulatory BP: A Randomized Controlled Trial, Clinical Journal of the American Society of Nephrology, Urate-lowering therapy for asymptomatic hyperuricaemia: A need for caution, Allopurinol as a therapeutic option in cardiovascular disease, Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options, Structure–activity relationships of fraxamoside as an unusual xanthine oxidase inhibitor, Journal of Enzyme Inhibition and Medicinal Chemistry, Is it Time to Find a Role for Uric Acid Levels in the Prevention and Management of Hypertension, 2016 updated EULAR evidence-based recommendations for the management of gout, Effect of uric acid-lowering therapy on blood pressure: systematic review and meta-analysis, Allopurinol and Cardiovascular Outcomes in Adults With Hypertension, Serum uric acid as a predictor of future hypertension: Stratified analysis based on body mass index and age, Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity, Allopurinol decreases serum uric acid level and intestinal glucose transporter-5 expression in rats with fructose-induced hyperuricemia, Hyperuricemia and the Prognosis of Hypertensive Patients: A Systematic Review and Meta‐Analysis, Xanthine oxidase gene variants and their association with blood pressure and incident hypertension, Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies, Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis, Biomarkers of Oxidative Stress in Human Hypertension, Gout and Hyperuricemia—Serious Risk Factors for Morbidity and Mortality or Just Indicators of “The Good Life”—The Evidence to Date, Uric Acid, Allopurinol: The Cardio-Renal Silver Bullet?, “Repurposing” of Xanthine Oxidoreductase as a Nitrite Reductase: A New Paradigm for Therapeutic Targeting in Hypertension, Serum uric acid and the risk of cardiovascular and renal disease, Allopurinol Protects against Ischemia/Reperfusion-Induced Injury in Rat Urinary Bladders, Effects of febuxostat on serum urate level in Japanese hyperuricemia patients, Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies, Impact of anti-inflammatory therapies, xanthine oxidase inhibitors and other urate-lowering therapies on cardiovascular diseases in gout, Renal Oxidative Stress Induced by Long-Term Hyperuricemia Alters Mitochondrial Function and Maintains Systemic Hypertension, Uric acid: association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patients, Allopurinol Initiation and Change in Blood Pressure in Older Adults With Hypertension, Febuxostat for Hyperuricemia in Patients with Advanced Chronic Kidney Disease, Selective fishing and analysis of xanthine oxidase binders from two Fabaceae species by coupling enzyme functionalized core–shell magnetic nanoparticles with HPLC–MS, Journal of the American Academy of Physician Assistants, Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia, Uric acid as a cardiorenal risk factor – ready for prime‐time?, Improving cardiovascular and renal outcomes in gout: what should we target?, The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality, Allopurinol on Hypertension: Insufficient Evidence to Recommend,

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