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Tell your doctor if you have or have ever had stomach ulcers or ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum). To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. The risk that you will develop liver damage may also be higher if you are elderly, obese, or have diabetes. However, you should not flush this medication down the toilet. Af- ter considerable improvement, the isotretinoin was ta- Volume 15 Number 2, Part 1 August, 1986 Atypical keloids after isotretinoin 281 Table I. Tell your doctor if you drink or have ever drunk large amounts of alcohol or if you have or have ever had liver disease. It is also sometimes used to treat Crohn's disease (condition in which the immune system attacks the lining of the digestive tract, causing pain, diarrhea, weight loss and fever) and other autoimmune diseases (conditions that develop when the immune system attacks healthy cells in the body by mistake). Store it at room temperature and away from excess heat and moisture (not in the bathroom).Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Information is also available online at It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. See the FDA's Safe Disposal of Medicines website (It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Methotrexate treats cancer by slowing the growth of cancer cells. If you experience signs of infection such as a sore throat, cough, fever, or chills, call your doctor immediately.If you take methotrexate while you are being treated with radiation therapy for cancer, methotrexate may increase the risk that the radiation therapy will cause damage to your skin, bones, or other parts of your body.Keep all appointments with your doctor and the laboratory. Ask your doctor about the safe use of alcoholic beverages while you are receiving methotrexate injection. Compare Aldactone vs Spironolactone head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate is also used to treat certain types of cancer including cancers that begin in the tissues that form around a fertilized egg in the uterus, breast cancer, lung cancer, certain cancers of the head and neck, certain types of lymphoma, and leukemia (cancer that begins in the white blood cells). The schedule depends on the condition you have and on how your body responds to the medication.Your doctor may tell you to take methotrexate on a rotating schedule that alternates several days when you take methotrexate with several days or weeks when you do not take the medication. Call your doctor immediately if you experience any of the following symptoms: nausea, extreme tiredness, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, or flu-like symptoms.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Methotrexate injection is also used along with rest, physical therapy and sometimes other medications to treat severe active rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that cannot be controlled by certain other medications. Call your doctor immediately if you experience any of the following symptoms: dry cough, fever, or shortness of breath.Methotrexate may cause damage to the lining of your mouth, stomach or intestines.

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