Hypobaric values were determined by subtracting BP data collected before administration of the drug from those collected after drug treatment at the corresponding time of day.
relative potency of CCBs as vasodilators varies, with dihydropyridine-type compounds, such as nifedipine, regarded as the most potent subclass, and verapamil, diltiazem, and bepridil as somewhat less potent.
Nineteen patients in the amlodipine group experienced at least one adverse event compared with 12 in the nifedipine coat-core group.
The hypobaric area was the area encircled between the 0 mmHg level line and the hypobaric curve. 2008 Sep;30(9):1618-28. doi: 10.1016/j.clinthera.2008.09.008.Kes S, Caglar N, Canberk A, Deger N, Demirtas M, Dortlemez H, Kiliccioglu B, Kozan O, Ovunc K, Turkoglu C.Curr Med Res Opin.
Taylor & Francis Systolic BP decreased -13.3 mmHg, and DBP BP -7.4 mmHg as daily averages. Unable to load your collection due to an error
2006;66(4):497-528. doi: 10.2165/00003495-200666040-00007. The hypobaric curve was drawn by plotting the hypobaric values in chronological order, with the time at which the drug was taken set as the starting point.
2011 Feb;71(2):244-9. doi: 10.1111/j.1365-2125.2010.03816.x.Clin Drug Investig. Clipboard, Search History, and several other advanced features are temporarily unavailable. The antihypertensive efficacy and safety of once-daily nifedipine coat-core was compared with that of once-daily amlodipine in a multicenter, prospective, double-blind, randomized, parallel-group study in which titration was based on response.
Data from 176 patients were valid for the primary efficacy analysis. During the study period, 59 (65.6%) nifedipine coat-core patients remained on their original 30-mg dose of study medication compared with 52 (60.5%) amlodipine patients who remained on the 5-mg starting dose. The total anti-hypertensive power of nifedipine coat-core, measured by the hypobaric area, was 1.69 times more potent than that of amlodipine. Clipboard, Search History, and several other advanced features are temporarily unavailable. Based on the EC50values, the potency of amlodipine in inhibiting PE-induced responses is significantly higher compared to nifedipine.
Treatment groups were well matched with respect to baseline demographic and disease characteristics. Amlodipine and Nifedipine are medications belonging to the group of calcium channel blockers primarily used to control high blood pressure.
Name must be less than 100 characters 2004 Aug;18(4):483-91. doi: 10.1111/j.1472-8206.2004.00269.x.Cochrane Database Syst Rev. To evaluate the effectiveness of anti-hypertensives on the temporal profile of BP, we proposed three new parameters obtained by ambulatory BP monitoring and evaluated these parameters by comparing 5 mg of amlodipine and 40 mg of nifedipine coat-core. Name must be less than 100 characters
Unable to load your collection due to an error 2003 Jan;25(1):35-57. doi: 10.1016/s0149-2918(03)90007-5.J Clin Hypertens (Greenwich).
Mean trough blood pressure at baseline was 160.9/101.9 mm Hg in the nifedipine coat-core patients compared with 160.5/101.8 mm Hg in the amlodipine patients. Taylor & Francis
Amlodipine is slightly soluble in the water on the other hand Nifedipine is insoluble in water. The total anti-hypertensive power of nifedipine coat-core, measured by the hypobaric area, was 1.69 times more potent than that of amlodipine.