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Pharmacokinetics: Absorption: Poorly absorbed in the gastrointestinal tract. Do not start, stop, or change the dosage of any medicine before checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. Nonprescription (over-the-counter) loperamide usually is taken immediately after each loose bowel movement but not more than the 24-hour maximum amount described on the label.
Loperamide, sold under the brand name Imodium, among others, is a medication used to decrease the frequency of diarrhea. It is often used for this purpose in, inflammatory bowel disease, and short bowel syndrome. Tell your doctor if have or have ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), a slow or irregular heartbeat, or a low level of potassium in your blood. Also tell your doctor if you are taking or plan to take any of the following medications: amiodarone (Nexterone, Pacerone), chlorpromazine, haloperidol (Haldol), methadone (Dolophine, Methadose), moxifloxacin (Avelox), pentamidine (Nebupent, Pentam), procainamide, quinidine (in Nuedexta), sotalol (Betapace, Betapace AF), thioridazine, and ziprasidone (Geodon). Do not take a double dose to make up for a missed one.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (Keep this medication in the container it came in, tightly closed, and out of reach of children. Take loperamide exactly as directed.If you are giving loperamide to your child, read the package label carefully to make sure that it is the right product for the age of the child.
See the FDA's Safe Disposal of Medicines website (In case of overdose, call the poison control helpline at 1-800-222-1222. doctor or pharmacist) know that you are taking these medicines together.
The strongest indication of loperamide addiction and dependence is the withdrawal symptoms that follow once you stop taking it. Unless otherwise directed by your doctor, take 4 milligrams (mg) of loperamide (2 capsules or tablets, or 4 teaspoonfuls of the oral solution dosage form) for the first dose, then 2 mg (1 capsule or tablet, or 2 teaspoonfuls of the oral solution dosage form) every 2 hours. Prescription loperamide is also used to control acute diarrhea and also ongoing diarrhea associated with inflammatory bowel disease (IBD; condition in which the lining of all or part of the intestine is swollen, irritated, or has sores). Use the measuring cup that came with the medication or use a spoon made especially for measuring liquid medication.If you are taking loperamide for acute diarrhea and your symptoms get worse or if your diarrhea lasts longer than 48 hours, stop taking this medication and call your doctor.This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.Drink plenty of water or other clear fluids to replace fluids lost while having diarrhea.If you are taking scheduled doses of loperamide, take the missed dose as soon as you remember it. Store it at room temperature and away from excess heat and moisture (not in the bathroom).It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily.
It is not recommended for those with blood in the stool, mucus in the stool or fevers. Description: Loperamide, an opioid agonist, binds to the opioid receptor directly in the gut wall on the circular and longitudinal intestinal muscles thereby, reduces propulsive peristalsis and prolong transit time, and enhances resorption of water and electrolytes.It also increases the tone on the anal sphincter. Follow the directions on the package or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
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