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European Levetiracetam Study GroupPlacebo‐controlled study of levetiracetam in idiopathic generalized epilepsyEffects of levetiracetam on spike and wave discharges in WAG/Rij ratsComparison of levetiracetam and controlled‐release carbamazepine in newly diagnosed epilepsyLevetiracetam, a new antiepileptic agent: lack of in vitro and in vivo pharmacokinetic interaction with valproic acidAbnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)Synaptic vesicle protein 2 enhances release probability at quiescent synapsesLevetiracetam: part II, the clinical profile of a novel anticonvulsant drugSelection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewedInfluence of levetiracetam on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 miceAnticonvulsant and behavioral effects of neuroactive steroids alone and in conjunction with diazepamucb L059, a novel anti‐convulsant drug: pharmacological profile in animalsEffects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsySubstantia nigra: site of anticonvulsant activity mediated by gamma‐aminobutyric acidSynergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?SV2A protein is a broad‐spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsySynergism between drugs with diffrent mechanisms of action against audiogenic seizures in DBA/2 miceEvidence for a unique profile of levetiracetam in rodent models of seizures and epilepsyLevetiracetam: the preclinical profile of a new class of antiepileptic drugs?Levetiracetam enhances markedly the seizure suppression of other antiepileptic drugs in amygdala‐kindled ratsElectrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsyCombination therapy in epilepsy: when and what to useProfile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and ratsLow doses of NMDA receptor antagonists synergistically increase the anticonvulsant effect of the AMPA receptor antagonist NBQX in the kindling model of epilepsyOver‐additive anticonvulsant effect of memantine and NBQX in kindled ratsThe novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulataAntiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsyValproate: a reappraisal of its pharmacodynamic properties and mechanisms of actionIsobolographic and subthreshold methods in the detection of interactions between oxcarbazepine and conventional antiepileptics—a comparative studyLevetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in micePharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysisLevetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock modelThe synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetamReduction of voltage‐operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action?Levetiracetam enhances markedly the seizure suppression of other antiepileptic drugs in audiogenic susceptible miceAnticonvulsant effects of levetiracetam and levetiracetam‐diazepam combinations in experimental status epilepticusAttenuated sensitivity to  neuroactive steroids in gamma‐aminobutyrate type A receptor delta subunit knockout miceReluctant vesicles contribute to the total readily releasable pool in glutamatergic hippocampal neuronsVesicle pool heterogeneity at hippocampal glutamate and GABA synapsesLevetiracetam Inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in cultureLevetiracetam inhibits the high‐voltage‐activated CaThe N166 Levetiracetam Study Group.
Lacosamide (LCM) levels were unavailable. The antiepileptic drugs (AEDs) levetiracetam and carbamazepine have demonstrated their usefulness in the treatment of partial seizures in a new study.Carried out by the Vydehi Institute of Medical Sciences and Research Centre and Columbia Asia Hospital in Bangalore, the research aimed to compare the efficacy and safety of these drugs among patients with partial epilepsy.One Purpose: Levetiracetam (LEV) therapeutic range (20-40mg/L) and potential drug interactions were assessed in people with epilepsy (PWE). As carbamazepine and carbamazepine-epoxide blood levels were not altered during levetiracetam co-medication, a pharmacodynamic interaction is suggested. The estimated average prevalence of epilepsy is 6.8 per 1000 people in US, 5.5 per 1000 people in Europe, and 1.5 to 14 per 1000 people in Asia, respectively. In fact, levetiracetam's effects on voltage activated CaThe effects of combined treatments with levetiracetam and other anticonvulsants characterized by well‐defined mechanisms of action form an interesting pattern (Preferential effects of AEDs on discrete brain regions could also play important role in mediation of their antiseizure activity. ... Carbamazepine adverse effects - ataxia - somnolence - drug rashes - … Introduction. 2017 Aug 3;8:515. doi: 10.3389/fphar.2017.00515. 2015 Sep-Oct;15(5):260-2. doi: 10.5698/1535-7511-15.5.260.
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