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dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of type 2 diabetes. Chemsrc provides Sitagliptin phosphate monohydrate(CAS#:654671-77-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc.
216-219°C. : Sitagliptin: a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesSitagliptin: Profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes.Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive declineFor further information and support on Ph. Densità PubChem CID Sitagliptin phosphate(MK 0431 phosphate) is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts. : MK0431 reduces in vitro migration of isolated splenic CD4 T-cells through a pathway involving cAMP/PKA/Rac1 activation [2]. Vedi quanti altri hanno usato Sitagliptin (CAS 486460-32-6).
Melting Point. Stato fisico Sitagliptin phosphate monohydrate (CAS NO.654671-77-9) was approved by the U.S. Food and Drug Administration (FDA) on October 17, 2006 and is marketed in the US as Januvia by Merck & Co. On April 2, 2007, the FDA approved an oral combination of sitagliptin and metformin marketed in the US as Janumet.1、Sitagliptin phosphate monohydrate (CAS NO.654671-77-9) works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). Packaging. Sitagliptin may cause an increased risk in the development of pancreatitis. Articles of Sitagliptin phosphate monohydrate … H 3 PO 4 2 O Sitagliptin Phosphate Monohydrate: OSHA Hazards: No known OSHA hazards This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones that are released in response to a meal.In clinical trials, adverse effects were as common with sitagliptin (whether used alone or with metformin or pioglitazone) as they were with placebo, except for extremely rare nausea and common cold-like symptoms.There is no significant difference in the occurrence of hypoglycemia between placebo and sitagliptin .
Packaging. Sitagliptin Phosphate is the phosphate salt form of sitagliptin, an orally available, competitive, beta-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DDP-4) with hypoglycemic activity.
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Clicca sulla voce per laccesso a PubMed Melting Point (°C) 101 - 200 (1) Color. C₁₆H₁₅F₆N₅O•H₃PO₄•H₂O. Adobe Acrobat Reader necessario per una visualizzazione affidabile, Flash point No data available. off-white (1) Application. 2016. CAS No. Odour threshold No data available. About 0% of these are Phosphate, 0% are Plastic Auxiliary Agents, and 0% are Other Chemicals. Valori pK : Numero MDL Sitagliptin phosphate (425508009) Definition A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Sitagliptin Phosphate is the phosphate salt form of sitagliptin, an orally available, competitive, beta-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DDP-4) with hypoglycemic activity. 216-219°C. C₁₆H₁₅F₆N₅O•H₃PO₄•H₂O. Melting Point : 110-120° C. Boiling Point : ~529.9° C at 760 mmHg (Predicted) Density : ~1.6 g/cm 3 (Predicted) Refractive Index : ... Sitagliptin (CAS 486460-32-6) Product Citations See how others have used Sitagliptin (CAS 486460-32-6). Endocrine. 654671-77-9 (Sitagliptin phosphate monohydrate) CAS No: 654671-77-9; Molecular Weight: 523.32408; Molecular Formula: C 16 H 20 F 6 N 5 O 6 P; Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product Computational chemical data
Accettando l'iscrizione, ha indicato che ha letto e accettato i termini della nostra : 523.33 ≥98%(HPLC) White Solid. CONSERVAZIONE : 0 oggetti nel tuo carrello della spesa
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Non hai un account? In this paper, ... Melting point: T peak = 202.4 °C: T peak = 197.9 °C: T peak = 196.4 °C: T peak = 202.1 °C: The water content was used to calculate the hydrate stoichiometry of the phases as given by eqn (1): Hydrate stoichiometry (1) The stoichiometric … Initial boiling point and range No data available.
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