";s:4:"text";s:4601:"(1987): The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. Richman DD, Fischl MA, Grieco MH, et al. These keywords were added by machine and not by the authors. Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: A novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Gottlieb MS, Wolfe PR, Chafey S (1987): Case report: Response of AIDS-related thrombocytopenia to intravenous and oral azidothymidine (3′-azido-3′-de-oxythymidine). Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS. Yarchoan R, Klecker RW, Weinhold KJ, et al. Gill PS, Rarick M, Brynes RK, Causey D, Loureiro C, Levine AM (1987): Azidothymidine associated with bone marrow failure in the Acquired Immunodeficiency Syndrome (AIDS). Mendeley BibTeX EndNote Glinski RP, Khan MS, Kalmas RL, Sporn MB (1973): Nucleoside synthesis. Zidovudine altered the normal muscle energy metabolism in the patients with myopathy, suggesting that it reduces maximal work output, and thus the maximal rate of mitochondrial ATP synthesis, in human muscle.In a pharmacokinetic study of three doses of zidovudine 300 mg 3-hourly in pregnancy in six subjects plasma zidovudine concentrations were substantially lower than previously reported during continuous intravenous therapy [Ribavirin reduces phosphorylation of zidovudine and antagonizes the antiviral activity; co-administration is not advised. Of greatest long-term concern is the interference of zidovudine with the normal function of mtDNA polymerase-γ. RefWorks (1986): Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Zidovudine can also cause dose-limiting toxicities of anemia and granulocytopenia. Lactic acidosis, hepatic steatosis, peripheral neuropathy, lipodystrophic/lipoatrophic changes, and myopathy all appear to be related to the mitochondrial toxicities associated with zidovudine. Phosphorylated 3′-amino-3′-deoxythymidine and 5′-amino-5′ deoxythymidine and derivatives.
WARNING: RISK OF HEMATOLOGICAL TOXICITY, MYOPATHY, LACTIC ACIDOSIS.