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The product does not contain a preservative, therefore microbial stability cannot be guaranteed. Refill Prescriptions Transfer Prescriptions Learn More. Connect With Us. – Presence of tumour in lower abdomen, bulky abdominal disease In patients treated with ifosfamide, reactivation has been reported for various viral infections.Close haematologic monitoring is recommended.
The serum half-life ranges between 4 - 8 hours depending on the dose and dosage regimen. • known hypersensitivity to ifosfamide. Use of live vaccines may lead to vaccine induced infection.Tamoxifen: Concomitant use of tamoxifen and chemotherapy may increase the risk of thromboembolic complications.Cisplatin: Cisplatin-induced hearing loss can be exacerbated by concurrent ifosfamide therapy (see also interactions above).Irinotecan: Formation of the active metabolite of irinotecan may be reduced when irinotecan is administered with ifosfamide.Alcohol: In some patients, alcohol may increase ifosfamide-induced nausea and vomiting.Concurrent administration of antidiabetic agents, such as sulfonylureas and ifosfamide may enhance the hypoglycaemic effects of the former drugs.Theoretical interactions of ifosfamide and allopurinol resulting in an increased severity of bone marrow depression.The administration of ifosfamide during organogenesis has been shown to have a fetotoxic effect in mice, rats, and rabbits and therefore may cause fetal damage when administered to pregnant women.There are only very limited data available on the use of ifosfamide during pregnancy in humans. Protective plastic overwrap does not come into contact with the medicinal product and provides additional transport protection, which increases the safety for the medical and pharmaceutical personnel.Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.Before parenteral administration, the substance must be completely dissolved.The following protective recommendations are advised during handling due to the toxic nature of the substance:Reconstitution and administration must be undertaken only by trained personnel. Re-treatment has been given following relapse.During or immediately after administration, adequate amounts of fluid should be ingested or infused to force diuresis in order to reduce the risk of urothelial toxicity. This may alter the effectiveness of ifosfamide treatment.
This should be considered when selecting the dose and interpreting response to the dose selected. Low serum albumin and hepatic impairment are also considered risk factors for the development of CNS toxicity. Patients receiving such combinations must be monitored closely for signs of toxicity to permit timely intervention.Patients being treated with ifosfamide and agents that reduce its activation should be monitored for a potential reduction of therapeutic effectiveness and the need for dose adjustment.Increased haematotoxicity and/or immunosuppression may result from a combined effect of ifosfamide and, for example: Vials are packed singly in a cardboard box.Vials are packed with or without a protective plastic overwrap.
mesna 200mg vesicare 5mg tab diovan 40mg tab lyrica 75mg secretin 16 mcg 1535 topamax 100mg 30 mupirocin 2% ud 9.47 cortrosyn 0.25 mg inj 436 pregabalin 75 mg cap ... ditropan xr 5mg tab colocort enema 60ml roxicodone 20mg/ml solut benalid 240ml m.w. Low serum albumin and hepatic impairment are also considered risk factors for the development of CNS toxicity. Fetal growth retardation and neonatal anaemia have been reported following exposure to ifosfamide-containing chemotherapy regimens during pregnancy. Each litre should be given over eight hours, and should be freshly made up immediately before infusion.Care should be taken that extravasation does not take place, however, should it occur local tissue damage is unlikely and no specific measures need be taken. Spillage should be removed by dry or moist disposable towels.Care must be taken in the disposal of all waste material (syringes, needles and disposable towels etc.) In those with no metastases at baseline, there was a statistically significant improvement in 5 year survival for those receiving ifosfamide /etoposide (69%) compared to those on standard treatment alone (54%). Various dosage schedules and regimens, in combination with other antitumour agents, have been used.
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